类Hotkey.cs
using System;
namespace Durius.Generics
{
public delegate void HotkeyEventHandler(int HotKeyID);
/// <summary>
/// System wide hotkey wrapper.
///  
/// Robert Jeppesen
/// Send bugs to robert@durius.com
/// </summary>
public class Hotkey : System.Windows.Forms.IMessageFilter
{
  System.Collections.Hashtable keyIDs = new System.Collections.Hashtable();
  IntPtr hWnd;
  /// <summary>
  /// Occurs when a hotkey has been divssed.
  /// </summary>
  public event HotkeyEventHandler OnHotkey;
  public enum KeyFlags
  {
   MOD_ALT = 0x1,
   MOD_CONTROL = 0x2,
   MOD_SHIFT = 0x4,
   MOD_WIN = 0x8
  }
  [System.Runtime.InteropServices.DllImport("user32.dll")]
  public static extern UInt32 RegisterHotKey( IntPtr hWnd, UInt32 id,
   UInt32 fsModifiers, UInt32 vk);
  [System.Runtime.InteropServices.DllImport("user32.dll")]
  public static extern UInt32 UnregisterHotKey( IntPtr hWnd, UInt32 id);
  [System.Runtime.InteropServices.DllImport("kernel32.dll")]
  public static extern UInt32 GlobalAddAtom( String lpString );
  [System.Runtime.InteropServices.DllImport("kernel32.dll")]
  public static extern UInt32 GlobalDeleteAtom( UInt32 nAtom );
  /// <summary>
  /// Constructor.  Adds this instance to the MessageFilters so that this class can raise Hotkey events
  /// </summary>
  /// <param name="hWnd">A valid hWnd, i.e. form1.Handle</param>
  public Hotkey(IntPtr hWnd)
  {
   this.hWnd = hWnd;
   System.Windows.Forms.Application.AddMessageFilter(this);
  }
  /// <summary>
  /// Register a system wide hotkey.
  /// </summary>
  /// <param name="hWnd">form1.Handle</param>
  /// <param name="Key">Your hotkey</param>
  /// <returns>ID integer for your hotkey. Use this to know which hotkey was divssed.</returns>
  public int RegisterHotkey(System.Windows.Forms.Keys Key, KeyFlags keyflags)
  {
    UInt32 hotkeyid = GlobalAddAtom(System.Guid.NewGuid().ToString());
    RegisterHotKey( (IntPtr)hWnd, hotkeyid, (UInt32)keyflags, (UInt32)Key);
    keyIDs.Add(hotkeyid, hotkeyid);
    return (int)hotkeyid;
  }
  /// <summary>
  /// Unregister hotkeys and delete atoms.
  /// </summary>
  public void UnregisterHotkeys()
  {
   System.Windows.Forms.Application.RemoveMessageFilter(this);
   foreach (UInt32 key in keyIDs.Values)
   {
    UnregisterHotKey(hWnd, key);
    GlobalDeleteAtom(key);
   }
  }
  public bool PreFilterMessage(ref System.Windows.Forms.Message m)
  {
   if (m.Msg == 0x312) /*WM_HOTKEY*/
   {
    if(OnHotkey != null)
    {
     foreach (UInt32 key in keyIDs.Values)
     {
      if((UInt32)m.WParam == key)
      {
       OnHotkey((int)m.WParam);
       return true;
      }
     }
    }
   }
   return false;
  }
}
}

测试程序Form1.cs
using System;
using System.Drawing;
using System.Collections;
using System.ComponentModel;
using System.Windows.Forms;
using System.Data;
using Durius.Generics;
namespace TestGenerics
{
/// <summary>
/// Summary description for Form1.
/// </summary>
public class Form1 : System.Windows.Forms.Form
{
  Hotkey hotkey;
  int Hotkey1;
  int Hotkey2;
  private System.Windows.Forms.Label label1;
  private System.Windows.Forms.Label label2;
  private System.Windows.Forms.Label label3;
  private System.Windows.Forms.Button button1;
  /// <summary>
  /// Required designer variable.
  /// </summary>
  private System.ComponentModel.Container components = null;
  public Form1()
  {
   //
   // Required for Windows Form Designer support
   //
   InitializeComponent();
   /*
    * Initialize our hotkeys. Pass in a handle to the main form in the constructor,
    *  then call RegisterHotkey for each of our hotkey combinations and wire up
    * the event
    */
   hotkey = new Hotkey(this.Handle);
   Hotkey1 = hotkey.RegisterHotkey(System.Windows.Forms.Keys.D1, Hotkey.KeyFlags.MOD_WIN);
   Hotkey2 = hotkey.RegisterHotkey(System.Windows.Forms.Keys.D2, Hotkey.KeyFlags.MOD_CONTROL);
   hotkey.OnHotkey += new HotkeyEventHandler(OnHotkey);
  }
  /// <summary>
  /// The hotkey event handler. If you have several hotkeys, you will have to check
  /// which one was divssed using HotkeyID.
  /// RegisterHotkey returns the HotkeyID that was assigned to your hotkey.
  /// </summary>
  /// <param name="HotkeyID"></param>
  public void OnHotkey(int HotkeyID)
  {
   this.Activate();
   if(HotkeyID == Hotkey1)
   {
    MessageBox.Show("WIN+1 divssed.");
   }
   else if(HotkeyID == Hotkey2)
   {
    MessageBox.Show("CTRL+2 divssed.");
   }
  }
  /// <summary>
  /// Clean up any resources being used.
  /// </summary>
  protected override void Dispose( bool disposing )
  {
   if( disposing )
   {
    hotkey.UnregisterHotkeys();
    if (components != null)
    {
     components.Dispose();
    }
   }
   base.Dispose( disposing );
  }
  #region Windows Form Designer generated code
  /// <summary>
  /// Required met